Need some additional research work and updates to my research paper attached according to the e feedback below
The feedback and guidelines as below
These are the edits given
Reviewers feedback we need to incorporate as below
I want to see a chart with sevoflurane (plotted in increasing concentration) on the x-axis, the other drugs (plotted as discrete ordinal points) on the Z-axis and the EDA reduction percent (difference from control) on the Y-axis. Please do this for all the drugs in the studies incorporated in the review. The data points will be indicative of which drugs; when combined with seviflurane provide greater reduction in EDA.
Next, I want to see drug classes (not individual drugs) plotted as discrete ordinal points on the Z-axis with the average of their percent reduction in EDA (for that class of drugs) on the Y-Axis. The X-axis is sevoflurane concentration (as before in point 1). For example, plot clonidine and dexmedetomidine together as alpha2 agonists, plot Tramodol and remifentanil together as opioids, plot propofol as GABA agonist, plot Remimazolam as benzodiazepene and Ketamine as NMDA antogonist. You are plotting drug classes in this figure, not individual drugs (except in those cases where there is only one drug in that class). This chart will be indicative of whether there is a mechanism of action synergy or additive effect in the reduction of EDA. for example, Sevoflurane has GABA agonist and NMDA antagonist effects. Ketamine is an NMDA antogonist while propofol is a GABA agonist. If it turns out that the combination of Sevoflurane and ketamine or the combination of Sevoflurane in propofol is relatively more effective at reducing EDA than other drugs, it may be that this is because they act by similar mechnisms? This may mean that -counterintuitively – a larger dose of Sevoflurane (lesser bispectral index, deeper anesthesia) may be better in reducing EDA than a smaller dose (greater bispectral index, shallower anesthesia) ? Plotting these graphs provides directionality to investigation and hypotheses formulation.
I then want to see a chart similar to 1 where the Z-axis will consist of 2 points (administered concurrently (point 1) or administered as wash-out (point 2) toward the end of sevoflurane anesthesia. This will inform if there is difference in EDA reduction if a drug is administered concurrently or as a wash-out (toward the end of the anesthetic procedure on Sevoflurane).
You have not discussed the depth of anesthesis in your report. Please report the bispectral index for each study. If not reported, check the dosage of Sevoflurane administered and find the bispectral index. Report the bispectral index for each study, then circle around to point 2 for explanation and discussion.
In the references section, if an article has more than 6 authors, all the 6 authors must be listed followed by et al. Please check and correct where necessary.
Reviewers feedback we need to incorporate as below
I want to see a chart with sevoflurane (plotted in increasing concentration) on the x-axis, the other drugs (plotted as discrete ordinal points) on the Z-axis and the EDA reduction percent (difference from control) on the Y-axis. Please do this for all the drugs in the studies incorporated in the review. The data points will be indicative of which drugs; when combined with seviflurane provide greater reduction in EDA.
Next, I want to see drug classes (not individual drugs) plotted as discrete ordinal points on the Z-axis with the average of their percent reduction in EDA (for that class of drugs) on the Y-Axis. The X-axis is sevoflurane concentration (as before in point 1). For example, plot clonidine and dexmedetomidine together as alpha2 agonists, plot Tramodol and remifentanil together as opioids, plot propofol as GABA agonist, plot Remimazolam as benzodiazepene and Ketamine as NMDA antogonist. You are plotting drug classes in this figure, not individual drugs (except in those cases where there is only one drug in that class). This chart will be indicative of whether there is a mechanism of action synergy or additive effect in the reduction of EDA. for example, Sevoflurane has GABA agonist and NMDA antagonist effects. Ketamine is an NMDA antogonist while propofol is a GABA agonist. If it turns out that the combination of Sevoflurane and ketamine or the combination of Sevoflurane in propofol is relatively more effective at reducing EDA than other drugs, it may be that this is because they act by similar mechnisms? This may mean that -counterintuitively – a larger dose of Sevoflurane (lesser bispectral index, deeper anesthesia) may be better in reducing EDA than a smaller dose (greater bispectral index, shallower anesthesia) ? Plotting these graphs provides directionality to investigation and hypotheses formulation.
I then want to see a chart similar to 1 where the Z-axis will consist of 2 points (administered concurrently (point 1) or administered as wash-out (point 2) toward the end of sevoflurane anesthesia. This will inform if there is difference in EDA reduction if a drug is administered concurrently or as a wash-out (toward the end of the anesthetic procedure on Sevoflurane).
You have not discussed the depth of anesthesis in your report. Please report the bispectral index for each study. If not reported, check the dosage of Sevoflurane administered and find the bispectral index. Report the bispectral index for each study, then circle around to point 2 for explanation and discussion.
In the references section, if an article has more than 6 authors, all the 6 authors must be listed followed by et al. Please check and correct where necessary.