Construct a 5- to 6-page paper discussing each of the four traditional mood stabilizer medications: carbamazepine, lamotrigine, lithium, and valproate products. Support your answers with five (5) evidence-based, peer-reviewed scholarly literature.
Note: APA style format will apply.
Your paper should include the following for each:
- Proposed mechanism of action
- Baseline assessment, laboratory considerations, and frequency of ongoing labs and assessments
Note:Discuss the importance of assessment and labs. - Special population considerations (birth assigned gender, age, other medical comorbidity considerations)
- FDA approval indications
- Typical dosing with discussion on therapeutic endpoints for psychiatric use
- Major drug–drug interaction considerations
- For each of these medications, please review potential drug–drug interactions listed below. Consider alternative dosing schedules, clinical implications for the drug interactions, additional patient education needed, any additional monitoring recommended, or collaboration needed with other medical professions (such as, primary care providers)
- Lamotrigine + Valproate
- Lamotrigine + Rifampin
- Valproate + Estrogen containing birth control.
- Valproate + Amitriptyline
- Lithium + Furosemide
- Lithium + Lisinopril
- Carbamazepine + Lurasidone
- Carbamazepine + Grapefruit juice
- Discuss the ethical, legal, and social implications related to prescribing bipolar and other related mood-disorder diagnoses therapy for patients.
- For each of these medications, please review potential drug–drug interactions listed below. Consider alternative dosing schedules, clinical implications for the drug interactions, additional patient education needed, any additional monitoring recommended, or collaboration needed with other medical professions (such as, primary care providers)
For each of the four (4) traditional mood stabilizers, response includes proposed mechanism of action, baseline assessment, laboratory considerations, and frequency of ongoing. Discusses the importance of assessment and labs. Indication of special population considerations FDA approval. Discusses typical dosing with focus on therapeutic endpoints for psychiatric use of major drug-drug interaction considerations.50 to >36 ptsExcellentThe response comprehensively and clearly describes all of the elements for each of the four (4) mood stabilizers.36 to >24 ptsGoodThe response clearly describes at least 75% the Assignment elements for three to four (3–4) mood stabilizers.24 to >11 ptsFairThe response describes at least 50% the Assignment elements for each mood stabilizer or only two (2) mood stabilizers discussed.11 to >0 ptsPoorThe response includes inaccurate and vague examples that describe 25% or less of the Assignment elements for one (1) mood stabilizer, or some or all are missing./ 50 ptsReviews the potential drug–drug interactions of the following: *Lamotrigine + Valproate; *Lamotrigine + Rifampin; *Valproate + Estrogen containing birth control; *Valproate + Amitriptyline; *Lithium + Furosemide; *Lithium + Lisinopril; *Carbamazepine + Lurasidone; *Carbamazepine + Grapefruit juice. Consider alternative dosing schedules, clinical implications for the drug interactions, additional patient education needed, any additional monitoring recommended, or collaboration needed with other medical professionals.20 to >18 ptsExcellentReviews all seven to eight (7-8) of the potential drug-drug interactions with clear and accurate Discussion of alternative dosing, patient education, monitoring recommendation, and when to collaborate.18 to >15 ptsGoodReviews five to six (5–6) of the potential drug-drug interactions with clear and accurate Discussion of alternative dosing, patient education, monitoring recommendation, and when to collaborate.15 to >10 ptsFairReviews three to four (3–4) of the potential drug-drug interactions with some Discussion and minor inaccuracies of alternative dosing, patient education, monitoring recommendation, and when to collaborate.10 to >0 ptsPoorReviews up to eight (8) of the potential drug-drug interactions with vague and major inaccuracies noted in the Discussion, including alternative dosing, patient education, monitoring recommendation, and when to collaborate./ 20 ptsDiscusses ethical, legal, and social implications related to prescribing these medications to patients.10 to >7 ptsExcellentThe response accurately and clearly discusses ethical, legal and social implications. The response includes relevant, specific, and appropriate examples that fully support the Discussion.7 to >4 ptsGoodThe response accurately discusses ethical, legal and social implications. The response includes relevant, specific, and accurate examples that support the Discussion.4 to >1 ptsFairThe response inaccurately or vaguely discusses ethical, legal and social implications. The response includes inaccurate and irrelevant examples that may support the Discussion.1 to >0 ptsPoorThe response inaccurately and vaguely discusses ethical, legal and social implications, or it is missing. The response includes inaccurate and vague examples that do not support the Discussion, or it is missing./ 10 ptsThe paper is succinct and is 5–6 pages. Five (5) evidence-based, peer- reviewed scholarly references outside of course resources.5 to >4 ptsExcellentThe paper is succinct and is 5–6 pages. Five (5) evidence-based, peer- reviewed scholarly references outside of course resources4 to >3 ptsGoodThe paper is succinct and is 7–8 pages. Four (4) evidence-based, peer- reviewed scholarly references outside of course resources3 to >1 ptsFairThe paper is somewhat succinct and is 8–9 pages. Two or three (2 or 3) evidence-based, peer- reviewed scholarly references outside of course resources1 to >0 ptsPoorThe paper is not succinct and is 10+ pages. One (1) or no evidence-based, peer- reviewed scholarly references outside of course resources/ 5 ptsWritten Expression and Formatting—Paragraph Development and Organization: Paragraphs make clear points that support well-developed ideas, flow logically, and demonstrate continuity of ideas. Sentences are carefully focused—neither long and rambling nor short and lacking substance. A clear and comprehensive purpose statement and introduction is provided which delineates all required criteria.5 to >4 ptsExcellentParagraphs and sentences follow writing standards for flow, continuity, and clarity. A clear and comprehensive purpose statement, introduction, and conclusion is provided which delineates all required criteria.4 to >3 ptsGoodParagraphs and sentences follow writing standards for flow, continuity, and clarity 80% of the time. Purpose, introduction, and conclusion of the Assignment is stated yet is brief and not descriptive.3 to >1 ptsFairParagraphs and sentences follow writing standards for flow, continuity, and clarity 60%–79% of the time. Purpose, introduction, and conclusion of the Assignment is vague or off topic.1 to >0 ptsPoorParagraphs and sentences follow writing standards for flow, continuity, and clarity less than 60% of the time. No purpose statement, introduction, or conclusion was provided./ 5 ptsWritten Expression and Formatting—English writing standards: Correct grammar, mechanics, and proper punctuation.5 to >4 ptsExcellentUses correct grammar, spelling, and punctuation with no errors.4 to >3 ptsGoodContains one or two grammar, spelling, and punctuation errors.3 to >1 ptsFairContains three or four grammar, spelling, and punctuation errors.1 to >0 ptsPoorContains five or more grammar, spelling, and punctuation errors that interfere with the reader’s understanding./ 5 ptsWritten Expression and Formatting: The paper follows correct APA format for title page, headings, font, spacing, margins, indentations, page numbers, parenthetical/in-text citations, and reference list.5 to >4 ptsExcellentUses correct APA format with no errors.