Context: This dissertation is for an Extended Project Qualification (EPQ)
Do consider the credibility of the soruce using the source using the acronym BABBLE (
| Bias, | Ability to see, | Balance, | Back-up/evidence, | Language, | Expertise) to evaluate’s source credibility |
Feel free to use any strucutre that would make the dissertation analytical enough to reach a conclusion about which treatment is most effective but here is a provided sample of the essay strcuture:
Introduction (Approx. 600 words)
- Alzheimer’s Disease Overview: Define Alzheimer’s disease, discuss its global prevalence, and underline its significance.
- Research Objective: Specify the aim to critically compare various Alzheimer’s treatments, emphasizing the analysis of their effectiveness in decelerating disease progression.
- Scope Definition: Detail the investigation’s scope, including pharmacological treatments, non-pharmacological interventions, and innovative therapies under development.
Background (Approx. 600 words)
- Pathophysiology Insights: Examine the biological mechanisms behind Alzheimer’s, including the roles of amyloid-beta plaques, tau protein tangles, and neurodegeneration.
- Diagnostic Evolution: Explore the evolution of diagnostic criteria for Alzheimer’s, focusing on biomarkers, neuroimaging, and cognitive assessments.
Pharmacological Treatments (Approx. 1500 words)
- Cholinesterase Inhibitors Analysis: Provide an in-depth analysis of cholinesterase inhibitors, discussing their pharmacodynamics, clinical trial outcomes, therapeutic efficacy, and adverse effects.
- Memantine Overview: Delve into Memantine’s pharmacology, trial data, therapeutic validity, and tolerability.
- Combination Therapy Examination: Critically review studies on the synergy between cholinesterase inhibitors and Memantine.
- Frontier Pharmacological Therapies: Survey emerging drugs targeting amyloid-beta, tau proteins, and other novel pathways, analyzing current trial phases and results.
Non-Pharmacological Interventions
- Cognitive Therapy Efficacy: Evaluate cognitive therapies, spotlighting their roles and impacts in Alzheimer’s management.
- Lifestyle Intervention Impacts: Investigate the effects of dietary, physical, and social interventions on Alzheimer’s progression.
- Technological Support: Assess the advancements in technology aiding Alzheimer’s patients, from wearables to digital monitoring tools.
Integrative Approaches
- Holistic Treatment Models: Analyze the effectiveness of integrating pharmacological and non-pharmacological treatments, with a focus on patient-centric outcomes.
- Towards Personalised Medicine: Explore the promise of personalised medicine in Alzheimer’s treatment, considering genetic and biomarker variability.
Challenges and Future Directions (Approx. 800 words)
- Diagnostic Barriers: Discuss the obstacles in achieving early and accurate Alzheimer’s diagnosis and their treatment implications.
- Identifying Research Voids: Highlight significant gaps in current research, especially in comprehending long-term therapeutic impacts and the disease’s molecular underpinnings.
- Prospective Therapeutic Avenues: Outline emerging research fields, such as immunotherapy and gene editing, as potential game-changers in Alzheimer’s therapy.
• Socioeconomic and Cultural Dynamics: Examine how socioeconomic and cultural contexts influence treatment accessibility and efficacy.
Conclusion (Approx. 400 words)
- Synthesis of Insights: Summarize the critical findings on the relative effectiveness of Alzheimer’s treatments.
- Practical Significance: Translate these findings into actionable insights for healthcare practitioners and caregivers.
- Talk about any limitations or challenges during the research
- Future Research Pathways: Propose directions for upcoming research, driven by the identified lacunas.
Writing Guidelines
- Commence with a Comprehensive Search: Utilize scholarly databases for a broad spectrum of relevant literature.
- Streamline References: Employ reference management software for efficient citation organization.
- Synthesize, Don’t Summarize: Aim for a synthesis of findings across studies to provide insightful analysis.
- Critique Methodologies: Offer a critical appraisal of the study designs and conclusions you review.
- Ensure Coherent Progression: Craft your narrative with logical progression, linking sections cohesively.
- Insightful Conclusion: Beyond summarizing, your conclusion should integrate findings into broader clinical and research contexts.