Biophysics Final Paper – Cell Sorting by Levitation at Micro and Macromolecular Scale

Guidelines for self-chosen paper write-upIf you get to pick a paper to be discussed in class, what paper would you choose? 


For this
assignment, identify a molecular/cell biology topic that interests you and find a paper on that
topic that you think would work well for our in class discussions. 

Next, prepare a 2-3 page paper
that addresses all of the points outlined below, including a “what’s next” section. 
For what’s next idea section:
With support from NATO’s SPS Programme, Gozde is leading a new research project aimed at developing a smart device that combines advanced nanotechnology and artificial intelligence to detect harmful microorganisms in water and air. Such a tool could be used to tackle bacterial contamination and improve the detection of pathogens in water and air on an everyday basis. It could also play a crucial security role in rapidly responding to attacks using biological agents, and help save many lives. Her project brings together her team at Stanford University in the United States along with research groups at Ozyegin University in Türkiye, and at the University of Aberdeen campus in Qatar.
* that is copied paragraph about one particular applciation of the magnetic levitation method Dr. Gozde Durmus developed
* Please also look at her prior works that you can find off of her Stanford Profile – Gozde Durmus, PhD
* Her idea of isolating cell populations based on magnetic and density signatures by separating them by magnetic levitation was precipitous of her prior work isolating cells with antiobiotic resistance, aimed at improving biomedical techniques for detecting antiobiotic resistance at early stages.

The idea of
this assignment is to get you to think like working scientists. 
1) Provide a summary of the paper 
a. What question or problem or hypothesis are the authors addressing? 
b. What is the bigger picture that gave rise to this question/problem/hypothesis? 
c. What are the major conclusions of the paper? 
d. What scientific advance did the paper make? 

2) Which of the topics/concepts we discussed in class does this paper illustrate and/or
expand upon? 
a. One paper can and often does integrate multiple topics/concepts. Be sure to
discuss all topics/concepts included in the paper. 
b. Where would you place this paper in the class schedule (e.g. after which lecture)?
c. Provide reasoning as to why you would you place the paper there. 

1) and 2) should take a single page, single-spaced

3) Pretend you are a brand new assistant professor and this is the work on which you will be
basing your lab’s research. 
Address the following: 
a. What is the next big question you would ask?
i. Clearly state your question and/or hypothesis. 
b. How would you experimentally address this question/hypothesis?
i. What experiments would you do and why? 
1. Provide a rationale for why you chose these experiments/approaches 
2. Describe the experimental plan 
3. Discuss possible outcomes of the experiment
ii. For the proposed experiments, the sky is the limit – meaning you have no
budgetary restraints and access to whatever reagents, equipment, and
facilities you need. 

3) Should be the bulk of the paper, applying course concepts -> taking 2 pages

iii. I will be reasonable in my expectations. 
Notes:
Points 1 and 2 should take ~1 page, while Point 3 should take ~1-2 pages, all singe-spaced.
Use your professor as a resource. I am more than willing to discuss and/or look over an outline

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