Considering the ideas set forth in Guns, Germs and Steel (and the associated videos), was the use of Slaves simply inevitable? Or is it due more to the rise of Mercantilist policies in this same period?

Guns Germs and Steel- http://tinyurl.com/zuah75fv
The Colombian Exhange – https://youtu.be/HQPA5oNpfM4
The Spanish Emipre – https://youtu.be/rjhIzemLdos
Must use quotes from Guns, Germs and Steel. 
Use ideas from the text and the videos 
Essay is on —- Opinion on if the use of slaves was inevitable? or If it was due more to the rise of Mercantilist policies.  ——Full essay topic below—– 
  1. We noticed that one of the key reasons as to why the Transatlantic Slave Trade became an economic “necessity” in the 16th and 17th centuries among the colonial powers was due to the exchange of diseases between Indigenous Peoples and European Colonizers, which killed a majority of potential labor in New World Plantations. Considering the ideas set forth in Guns, Germs and Steel (and the associated videos), was the use of Slaves simply inevitable? Or is it due more to the rise of Mercantilist policies in this same period?
Dropbox only seems to be working for the text, I have provided the videos and text above in links as well. 

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