Identifying Interaction Effects of Single Nucleotide Polymorphisms (SNPs) on Disease Ris

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I have a project to do with Framingham Heart Study Data to identify the interactions effects of single nucleotide polymorphisms on disease risk. using machine learning model like XGboost, Random forest, This data set contains 6719 observations and 49073 variables. could you please give Quote for this works

I have a project to do with Framingham Heart Study Data to identify the interactions effects of single nucleotide polymorphisms on disease risk. using machine learning model like XGboost, Random forest, This data set contains 6719 observations and 49073 variables. 

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