Obesity: Exploring the Role of Locus Coeruleus GLP-1 Receptors in Food Intake, Nausea-like Behavior, and Autonomic Physiological Responses

Research paper to evaluate: The locus coeruleus contributes to the anorectic,

nausea, and autonomic physiological effects of glucagon-like peptide-1 (uploaded pdf of it) 


Focus on this paper in explaining this area of research. Use only 1 other outside source (reliable) and 1 other research paper that can help explain the findings/significance. 


The written research paper should evaluate the current state of knowledge in the area of research in a broader context.

Consider this assignment to be a ‘deep dive’ into the topic of the primary research paper you selected using the Research Article Summary Form as a guide. Your aim is to convince the reader that you understand the topic area being studied, can follow the research conducted, and have an idea of where this line of research might be headed in the future.

As you organize and prepare your submission, keep in mind the goal of this assignment is for you to show that you can learn about a current area of neuroscience research by learning from a current high-end article in the primary literature. You will not be there to explain what you write. As a result, what you write should reflect, on its own merit, what is in your head.


Organization of your Paper Submission

These are many ways for you to organize your paper. You have flexibility that should be based on what your topic is and how you feel you can best summarize research in your topic area. How you structure your writing is flexible, however, the content of what you include in your final submission should resemble questions on the Research Article Summary Form.

Things to note as you prepare your submission:

• Papers in the sciences tend to be extremely focused. Similarly, your summary paper should be focused on the research question being asked. You do not need many pages of background information unless it is explicitly important to the main point you are trying to make. For example, if your topic is something about Parkinson’s disease, there is no need to waste pages telling the reader how many people have this disease, how expensive it is, or how the disease is diagnosed by a clinician, etc. It is good for you to know these background things, these things do not belong in a focused summary paper that is based on the primary, peer reviewed scientific literature.

  • Papers in the sciences are organized logically and use headings (and sometimes subheadings). The names and order of your headings should reflect the main things that are important to what you are writing about and trying to convey in your paper. If you pay attention to almost anything you read in the sciences, including textbooks, you will notice headings to help organize, separate, and guide the reader. You should adopt a similar approach in writing your paper.

  • Papers in the sciences do not have surprise endings. In other words, your Introduction should say what your paper is going to be about. It should start by being general and end with being very specific

  • The Body of the paper should provide the evidence supporting the main point of your introduction. The evidence should come from the primary literature.

  • Papers in the sciences also don’t abruptly end without some sort of conclusion statement(s). The Summary/Conclusion at the end of the paper should recapitulate what you say is important in the Introduction.

  • The Research Article Summary Form is an excellent resource for helping you to understand the research area you are learning about.


Format the Paper in APA 

Use the title: Obesity: Exploring the Role of Locus Coeruleus GLP-1 Receptors in Food Intake, Nausea-like Behavior, and Autonomic Physiological Responses

Use headings

  • Introduction

  • Subjects

  • Methodology 

  • 3 important point to make for the (this will be the body bit separate them into 3 different headings) 

  • Possible Next Steps 

  • Conclusion 

  • Reference  page (below is a citation to add) 

    • Fortin SM, Chen JC, Petticord MC, Ragozzino FJ, Peters JH, Hayes MR. The locus coeruleus contributes to the anorectic, nausea, and autonomic physiological effects of glucagon-like peptide-1. Sci Adv. 2023 Sep 22;9(38):eadh0980. doi: 10.1126/sciadv.adh0980. Epub 2023 Sep 20. PMID: 37729419; PMCID: PMC10511187.


USe these questions as a guide: 

2. What is the scientific question being investigated in this study? Use your own words. Answer succinctly in a couple of sentences.

 

3. Summarize (briefly) in general terms how the experiment was conducted.  

 


4. Who/what were the subjects of this research?

 

5. What was(were) the main thing(s) measured in this research paper.

 

 

6. Summarize the main findings of the paper.   (The main points conveyed by the figures and/or tables usually captures these things)  

 

 

7. Outline the flow of ideas in the Discussion section of the paper. In other words, what is the point of each paragraph in the Discussion section of the paper?

 

8. What concepts/aspects of this paper were difficult for you to understand?  

 

 

9. What scientific questions did this research stimulate you to think about? 

 

 

10. If this was your paper, what would you do next? Explain.


Find a similar study done to back up research, along with another reference. 

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