Write a research proposal that supports preclinical trials for the 4 FDA approved medications that were identified in the first source below. The other three sources provided will aid in making a convincing argument for starting these studies. These 4 sources are a must, with special emphasis on the first source. The remaining 4 sources should include how these medications may improve symptoms of the CYFIP2 R87C condition, benefits of drug repurposing, and how a study like this may advance future studies for specific genomic treatment approaches in other genetic variations. Our main focus of this paper is to make a convincing proposal on starting preclinical studies for the 4 identified medications for the CYFIP R87C variant.
source 1 (most important): Biomedicines | Free Full-Text | Identification of CYFIP2 Arg87Cys Ligands via In Silico and In Vitro Approaches (mdpi.com) https://www.mdpi.com/2227-9059/12/3/479
source 2: Generation of an induced pluripotent stem cell line from a patient with epileptic encephalopathy caused by the CYFIP2 R87C variant (fiocruz.br) https://www.arca.fiocruz.br/bitstream/handle/icict/60815/s13577-023-00978-4.pdf?sequence=2&isAllowed=y